Metabolic Profiling to Characterise Brain Tissues from a New Animal Model of Neurodegeneration with Lewy Body Pathology
نویسندگان
چکیده
P. C. Geiszler, L. Bedford, R. J. Mayer, D. P. Auer, and C. A. Daykin Division of Academic Radiology, School of Clinical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, Division of Molecular and Cellular Sciences, School of Pharmacy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghanshire, United Kingdom
منابع مشابه
Animal modeling an oligodendrogliopathy – multiple system atrophy
Multiple system atrophy (MSA) is a rare, yet rapidly-progressive neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. The definitive neuropathology differentiating MSA from Lewy body diseases is the presence of α-synuclein aggregates in oligodendrocytes (called glial cytoplasmic inclusion or GCI) rather than the fibrill...
متن کاملModels of α-synuclein aggregation in Parkinson’s disease
Parkinson's disease (PD) is not only characterized by motor disturbances but also, by cognitive, sensory, psychiatric and autonomic dysfunction. It has been proposed that some of these symptoms might be related to the widespread pathology of α-synuclein (α-syn) aggregation in different nuclei of the central and peripheral nervous system. However, the pathogenic formation of α-syn aggregates in ...
متن کاملMisfolded, protease-resistant proteins in animal models and human neurodegenerative disease.
Neurodegeneration in the substantia nigra has been known to be a constant feature of Parkinson disease (PD) since the early part of the twentieth century, when Trétiakoff (1) correlated the clinical findings of patients with PD with postmortem pathology. A few years earlier, Lewy had described concentric hyaline inclusions within neurons, which are now referred to as Lewy bodies (LBs) (2). LBs ...
متن کاملUptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease
Objective(s): Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The heart-tomediastinum ratio (H/M) in PD and DLB is significantly lower than that in Parkinson’s plus syndromes and Alzheimer’s disease. Although this ra...
متن کاملAdult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity.
BACKGROUND Neurodegeneration with brain iron accumulation is a rare neurodegenerative disorder characterized by iron deposition in the basal ganglia and neuroaxonal dystrophy. Familial cases with mutations in the pantothenate kinase gene are associated with a specific phenotype. In contrast, sporadic cases are heterogeneous in their clinical presentation. OBJECTIVE To describe an atypical cas...
متن کامل